14-3-3 proteins in the nervous system
Identifieur interne : 002077 ( Main/Corpus ); précédent : 002076; suivant : 00207814-3-3 proteins in the nervous system
Auteurs : Daniela Berg ; Carsten Holzmann ; Olaf RiessSource :
- Nature Reviews Neuroscience [ 1471-003X ] ; 2003-09.
Abstract
14-3-3 proteins are abundantly expressed in the brain and have been detected in the cerebrospinal fluid of patients with different neurological disorders. Although the function of this family of highly conserved proteins is not completely known, recent evidence indicates their involvement in multiple cellular processes. By their interaction with more than 100 binding partners, 14-3-3 proteins modulate the action of proteins that are involved in cell cycle and transcriptional control, signal transduction, intracellular trafficking and regulation of ion channels. The study of some of these interactions is sheding light on the role of 14-3-3 proteins in processes such as apoptosis and neurodegeneration.
Url:
DOI: 10.1038/nrn1197
Links to Exploration step
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After receiving her M.D. from Wrzburg University, she worked in the Department of Neurology of Wrzburg University from 1995 to 2002. Since 2002 she has been working on the study of neurodegenerative diseases at the University of Tbingen, combining clinical neurology, genetics and neuropathology.</note><affiliation>Daniela Berg works as a neurologist both in the Department of Medical Genetics and the Hertie Institute for Brain Research at the University of Tbingen. After receiving her M.D. from Wrzburg University, she worked in the Department of Neurology of Wrzburg University from 1995 to 2002. Since 2002 she has been working on the study of neurodegenerative diseases at the University of Tbingen, combining clinical neurology, genetics and neuropathology.</affiliation><affiliation>Institute for Human Genetics, Department of Medical Genetics, University of Tbingen, Calwerstrasse 7, 72076 Tbingen, Germany.</affiliation><affiliation>Hertie Institute for Brain Research, Rntgenweg 11, 72076 Tbingen, Germany.</affiliation></author><author><persName><forename type="first">Carsten</forename><surname>Holzmann</surname></persName><note type="biography">Carsten Holzmann is a staff researcher at the Department of Medical Genetics of the University of Rostock. He studied biology in Cologne and received his Ph.D. in 1998 from the Ruhr University, Bochum. His doctorate work was focused on the isolation and functional characterization of the huntingtin gene promoter of human and rat. His present research interests include the search for mutations in candidate genes for Parkinson's disease and the generation of animal models for neurodegenerative diseases.</note><affiliation>Carsten Holzmann is a staff researcher at the Department of Medical Genetics of the University of Rostock. He studied biology in Cologne and received his Ph.D. in 1998 from the Ruhr University, Bochum. His doctorate work was focused on the isolation and functional characterization of the huntingtin gene promoter of human and rat. His present research interests include the search for mutations in candidate genes for Parkinson's disease and the generation of animal models for neurodegenerative diseases.</affiliation><affiliation>Department of Medical Genetics, University of Rostock, Rembrandtstrasse 16/17, 18057 Rostock, Germany.</affiliation></author><author><persName><forename type="first">Olaf</forename><surname>Riess</surname></persName><note type="biography">Olaf Riess studied medicine at Humboldt University in Berlin. After receiving his M.D. he worked from 1990 to 1992 as a visiting scientist in the laboratory of M. Hayden (University of British Columbia, Vancouver, Canada) on Huntington's disease. After being Senior Scientist in the Department of Molecular Genetics at Ruhr University, Bochum, and Head of the Department of Medical Genetics of the University of Rostock, he became Professor of Medical Genetics at the University of Tbingen in 2001. His research focuses on neurodegenerative diseases as Huntington's disease, spinocerebellar ataxias and Parkinson's disease.</note><affiliation>Olaf Riess studied medicine at Humboldt University in Berlin. After receiving his M.D. he worked from 1990 to 1992 as a visiting scientist in the laboratory of M. Hayden (University of British Columbia, Vancouver, Canada) on Huntington's disease. After being Senior Scientist in the Department of Molecular Genetics at Ruhr University, Bochum, and Head of the Department of Medical Genetics of the University of Rostock, he became Professor of Medical Genetics at the University of Tbingen in 2001. His research focuses on neurodegenerative diseases as Huntington's disease, spinocerebellar ataxias and Parkinson's disease.</affiliation><affiliation>Institute for Human Genetics, Department of Medical Genetics, University of Tbingen, Calwerstrasse 7, 72076 Tbingen, Germany.</affiliation></author></analytic><monogr><title level="j">Nature Reviews Neuroscience</title><idno type="pISSN">1471-003X</idno><idno type="eISSN">1471-0048</idno><imprint><publisher>Nature Publishing Group</publisher><date type="published" when="2003-09"></date><biblScope unit="volume">4</biblScope><biblScope unit="issue">9</biblScope><biblScope unit="page" from="752">752</biblScope><biblScope unit="page" to="762">762</biblScope></imprint></monogr><idno type="istex">BCFB7F34724CB68FADF584F02B6E0EB0C093045D</idno><idno type="DOI">10.1038/nrn1197</idno><idno type="ArticleID">nrn1197</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2003</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>14-3-3 proteins are abundantly expressed in the brain and have been detected in the cerebrospinal fluid of patients with different neurological disorders. 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After receiving her M.D. from Würzburg University, she worked in the Department of Neurology of Würzburg University from 1995 to 2002. Since 2002 she has been working on the study of neurodegenerative diseases at the University of Tübingen, combining clinical neurology, genetics and neuropathology.</p></bio></cau><au><fnm>Carsten</fnm><snm>Holzmann</snm><inits>C</inits><orf rid="a3"></orf><bio><p>Carsten Holzmann is a staff researcher at the Department of Medical Genetics of the University of Rostock. He studied biology in Cologne and received his Ph.D. in 1998 from the Ruhr University, Bochum. His doctorate work was focused on the isolation and functional characterization of the huntingtin gene promoter of human and rat. His present research interests include the search for mutations in candidate genes for Parkinson's disease and the generation of animal models for neurodegenerative diseases.</p></bio></au><au><fnm>Olaf</fnm><snm>Riess</snm><inits>O</inits><orf rid="a1"></orf><bio><p>Olaf Riess studied medicine at Humboldt University in Berlin. After receiving his M.D. he worked from 1990 to 1992 as a visiting scientist in the laboratory of M. Hayden (University of British Columbia, Vancouver, Canada) on Huntington's disease. After being Senior Scientist in the Department of Molecular Genetics at Ruhr University, Bochum, and Head of the Department of Medical Genetics of the University of Rostock, he became Professor of Medical Genetics at the University of Tübingen in 2001. His research focuses on neurodegenerative diseases as Huntington's disease, spinocerebellar ataxias and Parkinson's disease.</p></bio></au><aff><oid id="a1"></oid><org>Institute for Human Genetics, Department of Medical Genetics, University of Tübingen</org>, <street>Calwerstrasse 7</street>, <zip>72076</zip> <cty>Tübingen</cty>, <cny>Germany</cny>.</aff><aff><oid id="a2"></oid><org>Hertie Institute for Brain Research</org>, <street>Röntgenweg 11</street>, <zip>72076</zip> <cty>Tübingen</cty>, <cny>Germany</cny>.</aff><aff><oid id="a3"></oid><org>Department of Medical Genetics, University of Rostock</org>, <street>Rembrandtstrasse 16/17</street>, <zip>18057</zip> <cty>Rostock</cty>, <cny>Germany</cny>.</aff><caff><coid id="c1"></coid><email>daniela.berg@uni-tuebingen.de</email></caff></aug><execsumm><p><list id="l1" type="bullet"><li>14-3-3 proteins are involved in the control of the cell cycle, transcription and apoptosis. Owing to their multiple interactions with various kinases, receptors, enzymes and structural and cytoskeletal proteins. Although the precise role of 14-3-3 proteins is not fully understood, they seem to control the subcellular localization of proteins and to function as adaptor molecules, stimulating protein–protein interactions.</li><li>There are seven known members of the 14-3-3 family, but genomic analysis points to the existence of several more. Crystallographic analysis of 14-3-3 proteins has led to the elucidation of their three-dimensional topology, and the identification of the domains that are involved in their dimerization and in their interaction with ligands.</li><li>The function of 14-3-3 proteins in the brain remains obscure, but they seem to participate in various physiological cellular processes such as signalling, cell growth, division, adhesion, differentiation, apoptosis and regulation of ion channels.</li><li>The presence of 14-3-3 proteins in the cerebrospinal fluid of people with Creutzfeldt–Jakob disease has prompted the suggestions that these proteins might be involved in the pathogenesis of this condition and that they might serve as disease biomarkers. Although it is not clear yet whether these suggestions correspond to reality, 14-3-3 proteins have also been implicated in other conditions such as Alzheimer's and Parkinson's diseases, and spinocerebellar ataxia type 1.</li><li>Future studies should focus on defining the precise roles of 14-3-3 proteins in neuronal physiology, and should try to obtain evidence for a causal relationship between the activity of 14-3-3 proteins and the disease states in which they have been implicated.</li></list></p></execsumm><abs><p>14-3-3 proteins are abundantly expressed in the brain and have been detected in the cerebrospinal fluid of patients with different neurological disorders. Although the function of this family of highly conserved proteins is not completely known, recent evidence indicates their involvement in multiple cellular processes. By their interaction with more than 100 binding partners, 14-3-3 proteins modulate the action of proteins that are involved in cell cycle and transcriptional control, signal transduction, intracellular trafficking and regulation of ion channels. The study of some of these interactions is sheding light on the role of 14-3-3 proteins in processes such as apoptosis and neurodegeneration.</p></abs></fm></article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="eng"><title>14-3-3 proteins in the nervous system</title></titleInfo><titleInfo type="alternative" lang="eng" contentType="CDATA"><title>14-3-3 proteins in the nervous system</title></titleInfo><name type="personal"><namePart type="given">Daniela</namePart><namePart type="family">Berg</namePart><affiliation>Institute for Human Genetics, Department of Medical Genetics, University of Tbingen, Calwerstrasse 7, 72076 Tbingen, Germany.</affiliation><affiliation>Hertie Institute for Brain Research, Rntgenweg 11, 72076 Tbingen, Germany.</affiliation><affiliation>E-mail: daniela.berg@uni-tuebingen.de</affiliation><role><roleTerm type="text">author</roleTerm></role><description>Daniela Berg works as a neurologist both in the Department of Medical Genetics and the Hertie Institute for Brain Research at the University of Tbingen. After receiving her M.D. from Wrzburg University, she worked in the Department of Neurology of Wrzburg University from 1995 to 2002. Since 2002 she has been working on the study of neurodegenerative diseases at the University of Tbingen, combining clinical neurology, genetics and neuropathology.</description></name><name type="personal"><namePart type="given">Carsten</namePart><namePart type="family">Holzmann</namePart><affiliation>Department of Medical Genetics, University of Rostock, Rembrandtstrasse 16/17, 18057 Rostock, Germany.</affiliation><role><roleTerm type="text">author</roleTerm></role><description>Carsten Holzmann is a staff researcher at the Department of Medical Genetics of the University of Rostock. He studied biology in Cologne and received his Ph.D. in 1998 from the Ruhr University, Bochum. His doctorate work was focused on the isolation and functional characterization of the huntingtin gene promoter of human and rat. His present research interests include the search for mutations in candidate genes for Parkinson's disease and the generation of animal models for neurodegenerative diseases.</description></name><name type="personal"><namePart type="given">Olaf</namePart><namePart type="family">Riess</namePart><affiliation>Institute for Human Genetics, Department of Medical Genetics, University of Tbingen, Calwerstrasse 7, 72076 Tbingen, Germany.</affiliation><role><roleTerm type="text">author</roleTerm></role><description>Olaf Riess studied medicine at Humboldt University in Berlin. After receiving his M.D. he worked from 1990 to 1992 as a visiting scientist in the laboratory of M. Hayden (University of British Columbia, Vancouver, Canada) on Huntington's disease. After being Senior Scientist in the Department of Molecular Genetics at Ruhr University, Bochum, and Head of the Department of Medical Genetics of the University of Rostock, he became Professor of Medical Genetics at the University of Tbingen in 2001. His research focuses on neurodegenerative diseases as Huntington's disease, spinocerebellar ataxias and Parkinson's disease.</description></name><typeOfResource>text</typeOfResource><genre type="review-article" displayLabel="Review"></genre><originInfo><publisher>Nature Publishing Group</publisher><dateIssued encoding="w3cdtf">2003-09</dateIssued><copyrightDate encoding="w3cdtf">2003</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="eng">14-3-3 proteins are abundantly expressed in the brain and have been detected in the cerebrospinal fluid of patients with different neurological disorders. Although the function of this family of highly conserved proteins is not completely known, recent evidence indicates their involvement in multiple cellular processes. 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|texte= 14-3-3 proteins in the nervous system
}}
| This area was generated with Dilib version V0.6.23. |  |